Alex Rodriguez's ninth-inning homer was upheld in baseball's first use of instant replay, and the New York Yankees beat the AL East-leading Tampa Bay Rays 8-4 on Wednesday night.

Rodriguez, who went 3-for-4 and drove in four runs, hit a towering two-run shot off Troy Percival that third base umpire Brian Runge immediately ruled a homer when it bounced off the catwalk behind the foul pole in left...